Pathogenesis of Middle East respiratory syndrome coronavirus
Identifieur interne : 001428 ( Main/Exploration ); précédent : 001427; suivant : 001429Pathogenesis of Middle East respiratory syndrome coronavirus
Auteurs : Judith Ma Van Den Brand [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Bart L. Haagmans [Pays-Bas]Source :
- The Journal of Pathology [ 0022-3417 ] ; 2015-01.
Descripteurs français
- KwdFr :
- Anatomopathologie moléculaire (), Animaux, Antiviraux (usage thérapeutique), Appareil respiratoire (), Appareil respiratoire (anatomopathologie), Appareil respiratoire (virologie), Biopsie, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Interactions hôte-pathogène, Pronostic, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Valeur prédictive des tests, Virologie (), Virulence, Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
- MESH :
- anatomopathologie : Appareil respiratoire, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Infections à coronavirus.
- virologie : Appareil respiratoire, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Anatomopathologie moléculaire, Animaux, Appareil respiratoire, Biopsie, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Interactions hôte-pathogène, Pronostic, Valeur prédictive des tests, Virologie, Virulence.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Biopsy, Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Coronavirus Infections (transmission), Coronavirus Infections (virology), Host-Pathogen Interactions, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Pathology, Molecular (methods), Predictive Value of Tests, Prognosis, Respiratory System (drug effects), Respiratory System (pathology), Respiratory System (virology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Virology (methods), Virulence.
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Respiratory System.
- drug therapy : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- methods : Pathology, Molecular, Virology.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathology : Coronavirus Infections, Respiratory System, Severe Acute Respiratory Syndrome.
- transmission : Coronavirus Infections.
- virology : Coronavirus Infections, Respiratory System, Severe Acute Respiratory Syndrome.
- Animals, Biopsy, Host-Pathogen Interactions, Humans, Predictive Value of Tests, Prognosis, Virulence.
Abstract
Human coronaviruses (CoVs) mostly cause a common cold that is mild and self‐limiting. Zoonotic transmission of CoVs such as the recently identified Middle East respiratory syndrome (MERS)‐CoV and severe acute respiratory syndrome (SARS)‐CoV, on the other hand, may be associated with severe lower respiratory tract infection. This article reviews the clinical and pathological data available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra‐alveolar organization with a bronchiolitis obliterans organizing pneumonia‐like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS‐CoV and SARS‐CoV. The challenge will be to translate these findings into an integrated picture of MERS pathogenesis in humans and to develop intervention strategies that will eventually allow the effective control of this newly emerging infectious disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Url:
- https://api.istex.fr/ark:/67375/WNG-F1MJTV87-T/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167882
DOI: 10.1002/path.4458
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000232
- to stream Istex, to step Curation: 000232
- to stream Istex, to step Checkpoint: 000139
- to stream PubMed, to step Corpus: 000F16
- to stream PubMed, to step Curation: 000F16
- to stream PubMed, to step Checkpoint: 000D78
- to stream Ncbi, to step Merge: 002974
- to stream Ncbi, to step Curation: 002974
- to stream Ncbi, to step Checkpoint: 002974
- to stream Pmc, to step Corpus: 001846
- to stream Pmc, to step Curation: 001846
- to stream Pmc, to step Checkpoint: 000870
- to stream Ncbi, to step Merge: 003F62
- to stream Ncbi, to step Curation: 003F62
- to stream Ncbi, to step Checkpoint: 003F62
- to stream Main, to step Merge: 001430
- to stream Main, to step Curation: 001428
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathogenesis of Middle East respiratory syndrome coronavirus</title><author><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5F0C5B753C70485D39CE10AEB85686C0E2D2D6BD</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1002/path.4458</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-F1MJTV87-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000232</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000232</idno><idno type="wicri:Area/Istex/Curation">000232</idno><idno type="wicri:Area/Istex/Checkpoint">000139</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000139</idno><idno type="wicri:doubleKey">0022-3417:2015:Van Den Brand J:pathogenesis:of:middle</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25294366</idno><idno type="wicri:Area/PubMed/Corpus">000F16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F16</idno><idno type="wicri:Area/PubMed/Curation">000F16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F16</idno><idno type="wicri:Area/PubMed/Checkpoint">000D78</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D78</idno><idno type="wicri:Area/Ncbi/Merge">002974</idno><idno type="wicri:Area/Ncbi/Curation">002974</idno><idno type="wicri:Area/Ncbi/Checkpoint">002974</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167882</idno><idno type="RBID">PMC:7167882</idno><idno type="wicri:Area/Pmc/Corpus">001846</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001846</idno><idno type="wicri:Area/Pmc/Curation">001846</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001846</idno><idno type="wicri:Area/Pmc/Checkpoint">000870</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000870</idno><idno type="wicri:Area/Ncbi/Merge">003F62</idno><idno type="wicri:Area/Ncbi/Curation">003F62</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F62</idno><idno type="wicri:doubleKey">0022-3417:2014:Van Den Brand J:pathogenesis:of:middle</idno><idno type="wicri:Area/Main/Merge">001430</idno><idno type="wicri:Area/Main/Curation">001428</idno><idno type="wicri:Area/Main/Exploration">001428</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Pathogenesis of Middle East respiratory syndrome coronavirus</title><author><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Pathology</title><title level="j" type="sub">Viruses and Disease</title><title level="j" type="alt">THE JOURNAL OF PATHOLOGY</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><biblScope unit="vol">235</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="175">175</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">10</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2015-01">2015-01</date></imprint><idno type="ISSN">0022-3417</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (therapeutic use)</term><term>Biopsy</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Pathology, Molecular (methods)</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Respiratory System (drug effects)</term><term>Respiratory System (pathology)</term><term>Respiratory System (virology)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virology (methods)</term><term>Virulence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anatomopathologie moléculaire ()</term><term>Animaux</term><term>Antiviraux (usage thérapeutique)</term><term>Appareil respiratoire ()</term><term>Appareil respiratoire (anatomopathologie)</term><term>Appareil respiratoire (virologie)</term><term>Biopsie</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (virologie)</term><term>Interactions hôte-pathogène</term><term>Pronostic</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Valeur prédictive des tests</term><term>Virologie ()</term><term>Virulence</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pathology, Molecular</term><term>Virology</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biopsy</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anatomopathologie moléculaire</term><term>Animaux</term><term>Appareil respiratoire</term><term>Biopsie</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Pronostic</term><term>Valeur prédictive des tests</term><term>Virologie</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Human coronaviruses (CoVs) mostly cause a common cold that is mild and self‐limiting. Zoonotic transmission of CoVs such as the recently identified Middle East respiratory syndrome (MERS)‐CoV and severe acute respiratory syndrome (SARS)‐CoV, on the other hand, may be associated with severe lower respiratory tract infection. This article reviews the clinical and pathological data available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra‐alveolar organization with a bronchiolitis obliterans organizing pneumonia‐like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS‐CoV and SARS‐CoV. The challenge will be to translate these findings into an integrated picture of MERS pathogenesis in humans and to develop intervention strategies that will eventually allow the effective control of this newly emerging infectious disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name></region><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001428 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001428 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5F0C5B753C70485D39CE10AEB85686C0E2D2D6BD
|texte= Pathogenesis of Middle East respiratory syndrome coronavirus
}}
| This area was generated with Dilib version V0.6.33. |  |